1blocker vs7/13/2023 Checkpoint blockade is highly effective in dMMR cancers, producing responses in about 10% of recipients, Dr. Clinical complete response was indicated by an endoscopic visual exam showing disappearance of the primary tumor along with a normal digital rectal exam the formal criteria for rectal MRI response also had to be met.Īpproximately 5% to 10% of rectal cancers are dMMR, and these tumors are relatively resistant to chemotherapy. Overall response was determined by rectal magnetic resonance imaging (MRI) and endoscopic exam tumors were graded as stable disease, having partial response, having near complete response, or having complete response. The primary objectives were overall response rate to PD-1 blockade with or without chemoradiation and pathologic complete response or clinical complete response rate at 12 months after PD-1 blockade with or without chemoradiation. Patients with clinical complete responses were then followed up nonoperatively every 4 months those with residual disease underwent chemoradiotherapy, after which clinical complete responders were followed nonoperatively and those with persistent residual disease underwent surgery. Patients received dostarlimab at 500 mg intravenously every 3 weeks for 6 months and then underwent radiologic and endoscopic evaluation. The standard of care for these patients would have very likely required all three modalities of chemotherapy, radiation, and surgery,” Dr. “I’d like to highlight that the majority of these patients had big bulky tumors, and 94% were node-positive. All patients had dMMR and BRAF V600E wild-type tumors the mean tumor mutational burden was 67. The median age was 54 years, but age has ranged from 26 to 78. Of the 18 patients enrolled to date, most (78%) have T3 or T4 rectal tumors. All but one patient has node-positive disease, and about half have Lynch syndrome. The single-arm phase II study will ultimately enroll 30 patients with clinical stage II and III dMMR rectal cancer. The 100% clinical complete response rate is unprecedented in rectal cancer, and the potential to decrease morbidity by eliminating pelvic radiation and surgery for our patients is huge,” said invited discussant Kimmie Ng, MD, MPH, Associate Professor of Medicine at Harvard Medical School and Co-Director of the Colon and Rectal Cancer Center at Dana-Farber Cancer Institute. “I think everyone in this room will agree that the results are clinically meaningful. Median follow-up is currently only 6.8 months, but four patients have been followed for nearly 2 years, and only four have received less than 6 months of the required treatment. There have been no disease recurrences observed … though longer follow-up is certainly required to establish the durability of this treatment.” No patients have required chemotherapy, radiation, or surgery. “We’ve now treated a total of 14 patients, and all-100%-have had a clinical complete response to dostarlimab alone…. “We were obviously beyond thrilled,” she said. Cercek conveyed the excitement her team felt as the first patients improved beyond expectations. The study was also simultaneously published in The New England Journal of Medicine.ĭr. The compelling results were presented at the 2022 ASCO Annual Meeting by Andrea Cercek, MD, Head of the Colorectal Cancer Section and Co-Director of the Center for Young-Onset Colorectal and Gastrointestinal Cancers at Memorial Sloan Kettering Cancer Center ( Abstract LBA5). So far, dostarlimab has spared every one of these patients of the need for chemotherapy, radiation, or surgery. In a study of patients with locally advanced mismatch repair–deficient (dMMR) rectal cancer, 6 months of treatment with the anti–PD-1 agent dostarlimab-gxly alone led to clinical complete responses in 100% of the study’s first 14 patients. Rarely, if ever, has one abstract presented at the ASCO Annual Meeting warranted its own session-but that happened with a small but mighty study from Memorial Sloan Kettering.
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Gpodder or juice7/13/2023 Or there’s a neat hack out there, a nifty combination of tools. It includes support for MP3 and mobile phone players. We’ve had performance issues for a while and I think I need to do some NGINX configuration work will keep everyone posted. gPodder is an easy to use podcast receiver that will download and manage your podcast subscriptions. If you've got podcast software installed on your computer (such as iTunes, Juice or gPodder) you can use the URL for the podcast feed to subscribe to your chosen podcast. If you refresh it a bunch, you eventually get in. Maybe there’s a little-known but excellent app. On the gpodder mailing list, maintainer fundatillus wrote on 30 November (today) to say: The service isn’t down exactly. So what do you recommend, readers, technologists, and podcast mavens? Perhaps Feedly on the desktop is an option, or Digg is going to support podcast downloading. Can organize individual feeds into a sequence.Should run on Windows (laptop) and Android (phone).After downloading a podcast, you can enjoy it in your favorite audio or video application or on your portable media player. Second, Stitcher seems to be streaming only, i.e., no downloads. Other free programs for managing podcast subscriptions include Juice (Mac and Windows) and gPodder (Linux and Windows). First, I spend a lot of time with poor or zero cell phone coverage, as I live in rural New England. In order to use these, youll need to refer to. I’ve toyed with Stitcher, but it doesn’t really meet my needs. This will usually involve the use of a podcatcher, such as iTunes, Juice, WinAMP, gPodder, BeyondPod, etc. On anyone can create an account relatively easily and the service is free to use. Moreover, I don’t buy music from iTunes, so using it solely as a podcatcher is overkill. How to synchronize between devices AntennaPod currently supports two synchronization options: via and the gPodder Sync app for Nextcloud. IRC channel: gpodder on (see for help with IRC) Where to discover new podcasts. I am opposed to the idea of commenting on feeds off the Web. It runs slowly on my (Windows) machine and hogs memory. Buy temovate online buy temovate no prescription generic Hand of fate 2 the far north7/13/2023 To tell the story of human migration in Alaska’s national parklands, we must consider the archaeological record of the entire state and the neighboring regions in Canada and Russia. This article describes human migrations into and through Alaska over the past 14,000 years to provide a better understanding of who created the archaeological sites found within Alaska’s national parklands. The timing and causes of these major population resettlements remain a major topic of archaeological interest, and understanding the nature of human migrations is a fundamental step toward interpreting the archaeological record. Archaeologists reserve the term colonization for those migration events of the first people into a new area. Archaeologists most commonly use the term migration to refer to long-distance moves with the intention of residing in a new location permanently. Ethnographic data show Native Alaskan populations typically limited their residential moves within familiar territories (e.g., Burch 2006) however, the archaeological record demonstrates there were times in prehistory when humans spread from their homelands to new areas, sometimes lands where humans had never lived before. Arctic hunters travel to a new camp near the sea.įrank and Frances Carpenter collection, Library of CongressĪncient hunter-gatherers of the Arctic and Subarctic regions were nomadic people that moved camp regularly with the seasons. Beatunes vs tangerine7/13/2023 THE COMPETITORS Beatport’s Key Detectionīeatport has their own detected key for almost every song in their catalog – which is why we started with their own catalog as a place to source tracks. If you disagree, feel free to make a case for a different consensus on a track in the comments. With that in mind, we’ve only used songs in our test that had a clear consensus (read: simple majority) from our human test group. Our test group included myself and 6 awesome well-suited volunteers with experienced ears (even a few perfect-pitch ears in the group) keying tracks from the DJTT community – thanks for listening to these tracks and helping out! It is possible that our ears are somewhat fallible, which is why we’re putting all of our data at the end of the article. We’ve heard from some sources that even a groups of pitch-perfect classically trained musicians have a significant rate of disagreement about the key of certain songs. It’s critical to not build a dependency on tools, but instead use them to augment a sense of when something works or doesn’t. We mention the old adage “trust your ears!” in almost every single article about harmonic mixing. The latter error is less likely to cause DJs an issue in the mix, as there’s still a good chance that it will share many of the same notes as the track that you’re mixing in to/out of. There wasn’t time before publication but it may be added here soon.Ĭommon errors that you’ll see notated in the results below include a mixup of major/minor – something that can be hard to detect even for a human at times, as well as “harmonically forgivable” analyses, which are off by 1 fifth. By that right, we took 61 of the top songs from Beatport, using all genres on the site, and ran them through our human testers and all 10 software options.Įditor’s Note: We’d really like to run a third test as another control that uses very common three chord progressions. Real World Test – Instead of doing a test with music across all kinds of genres, we decided to focus on what almost each of these applications claim to do well – music that DJs are commonly playing. The fascinating results below show how some applications are optimized for detecting chords and others struggle with telling if they’re major or minor. Major / Minor Triads (“Control”) – In this test, we constructed incredibly simple 30 second long songs with a drum loop and a piano playing a major or minor triad for the 24 keys. How does Traktor Pro fare versus Traktor DJ? Is Rekordbox reliable? Is the new Mixed In Key worth an upgrade? We last stood just three entrants against each other in a harmonic showdown in 2012, but this year we’ve got 12 different algorithms competing in our key detection comparison. Harmonic mixing has become an integral part of a lot of digital DJs arsenals, reflected by the presence of key detection algorithms in a variety of softwares. Block city wars all hidden coins7/13/2023
Supersync itunes android7/12/2023 In case you have audio files scattered across multiple computers and need to create a complete library which can be accessed from anywhere, then SuperSync is the answer to your questions. delete links to missing tracks, remove empty directories), perform searches, and check out a library overview with details about the total number of movies, TV shows, podcasts, voice memos, audio books, and other items. What’s more, you can search for tracks, analyze and repair library (e.g. You can compare tracks to identify duplicate items, remove duplicates, and delete items from the library. It is also able to signal several issues and filter the files by Missing Tags, File Duplicates, Possible Duplicates, No Artwork, or another criterion. The tool groups items into different categories, such as Movies and TV Shows. SuperSync lets you transfer the selected files from the remote library to the local one or vice versa, or sync data between the two libraries so you can have the same content on both computers. File transfers and library cleaning options You can filter files by genre, artist or album.Īside from the built-in player, the tool comes packed with a web server that allows you to view and listen to the items comprised in your library from any device that has a web browser. title, year, track).įiles can be played in iTunes or directly in the utility’s interface using the basic playback controls for playing, pausing or stopping the selection, and jumping to the next or previous item in the list. rating, date when the item was added, file location), and tags (e.g. name, size, time, format), iTunes info (e.g. Plus, you can make the app show detailed information about each track, namely general data (e.g. SuperSync reveals all items included in a library, along with information about the title, artist, album, genre, size, time, rating, and play count. The remote library is the one you can compare to. The local one represents the music library that SuperSync is running on, and reads the content of iTunes on that machine. You can work with local and remote libraries. The utility offers support for an online help manual that elucidates any misunderstandings that you may have regarding its settings. The GUI looks a bit overwhelming at a first glance because the tool comes packed with lots of filters and options to tweak. Plus, it works hand in hand with iTunes libraries. You can make comparisons, access, sync and merge iTunes files, such as audio items, podcasts and videos across multiple Macintosh and Windows PCs, iPhones, iPads, and iPods. SuperSync provides: unlimited synchronizing, duplicate removal, iTunes library repair, unlimited networking access, free product updates, satisfaction guarantee, even includes an integrated music player.SuperSync is an advanced software application whose purpose is to help you move and synchronize your audio files from one library to another. The highlights of SuperSync are: access your home iTunes library from anywhere remotely access any of your music libraries without subscriptions or fees visually compare and merge any two libraries on Mac OS X, Windows, and iOS easily browse for new music on iTunes and Amazon with a single keystroke consolidate libraries, remove duplicates, access your library from more computers, match more tracks, and upgrade the bit rates of matched tracks find problems that exist in your iTunes libraries, like duplicate tracks, orphaned files, and corrupt files easily move your music library from Windows to Mac, Mac to Windows, or any combination. SuperSync gives you all the features and capabilities you need to seamlessly and effortlessy manage your iTunes libraries, regardless of how many you have or how large they are. With SuperSync, it's fast, easy and intuitive. SuperSync seamlessly and intuitively lets you compare, organize, merge, and manage iTunes libraries across all of your Macs, PCs, and iOS devices. SuperSync is a professional-quality iTunes library management solution that's perfect for DJs, audio files, music collectors, video mavens, and anyone for whom music and video are major parts of their digital life. Veracrypt features7/12/2023 i used jdownloader to manage to download it. something last when i tried to download the file from dropbox with chrome or firefox both stopped the download and i couldnt resume. the file that i have uploaded is called PerW (without any extention indicating its a veracrypt file, doesnt need one i have deleted it for security reasons) right now the only thing i am thinking to do is to reupload the whole file (9GB), but thats the whole volume, files inside are less until they reach 9GB (which is maximum set filesize for veracrypt file, this is how veracrypt works)Īlso i need to say that i have done this test to far past time and it worked ok. Thats all i hope i helped if u need something else tell me to write for you. As VeraCrypt is not compatible with Android, iOS, or BSD, users of those operating systems will find alternatives available for them here as well. then i had a heart attack so i wrote here to find out why and how to prevent this from happening againĪll started when i noticed that when i closed (dismount) a veracypt file the dropbox did NOT sync anything (the icon on taskbar was like nothing happens, didnt have the sync icon next to it) Other features that VeraCrypt users might find lacking include the ability to integrate with Windows Explorer, as well as support for Universal Disk Format files. and the files inside where much less than my local veracrypt file. i mounted it on U:\ drive for example, could be any letter. VeraCrypt is a free and libre source (open source) disk encryption software brought to you by Features: Creates a virtual encrypted disk within a file and mounts it as a real disk. So what u see in screenshot is on the left side a W:\ drive (this is the local unencypted virtual drive) and on the right side the veracrypt file i downoloaded from internet to my desktop to open it to see whats in it. so it takes a little time to finish (it doesnt reupload 9 GB i mean) WHEN i dismount (close the virtual drive, encypt it again) the veracrypt file of mine THEN and ONLY THEN dropbox uses deltasync to sync the changes made to that huge file of mine of 9GB. after processing it, for example make a change in a word document, or a txt etc nothing yet happens with dropbox. it finished (after many hours cause it was 9GB) and for many time i think until recently some months now it worked.Ģ) The second screenshot is of the file after i downloaded it from your website YES! just for testing purposes (open, mounted)ģ) Now veracrypt is working with dropbox with this way: When i locally open (temporarilly decrypt) the veracrypt file (which i repeat its encrypted by me) i mount it (create) a virtual drive that contains everything my veracrypt file contains so that i can process it. Not sure what u mean here when i first installed dropbox then i put into the local folder of my PC a veracrypt encrypted file (called PerW). Hallo! thnx for helping me it is very important for me to have my personal files on the cloud, the best there is dropbox so.ġ) i always use dropbox desktop app to make things. Chemistry calculator texas instruments7/12/2023 It has a facility to store around 30 KB calculations and 800 memory registers.HP 35s scientific calculator offers calculation versatility in one inexpensive unit, which has over 100 built-in functions.The calculator also allows contrast adjustments. It provides a two-line LCD, which can contain 14 characters plus indicators.This product’s average battery life is more than nine months if you use it every day for an hour, which is better than any other scientific calculator available. This model from HP has excellent battery life, and as its display has a contrast feature, one can use it indoors and outdoors. This scientific calculator is not just helpful for chemistry but can also be useful for professionals in various fields such as surveying science, medicine, engineering, and more. The next option that I came across while searching for the scientific calculator for chemistry is this one by HP. If you need a ‘not-so-complicated’ scientific calculator, you should try this one for sure. Texas Instruments has manufactured a thoughtful and ideal calculator for high-school students as it is easy to use and easy to slip into a backpack.
Turning off norton internet security7/12/2023 Risk-Free for 60 Days – Try Norton Now Norton 360 Full Review Plus, Norton comes with a 60-day money-back guarantee and regularly offers free trials - giving you plenty of time to test it and see if it’s the right antivirus for you. Most competitors offer some extra features along with their basic anti-malware scanner, but almost all of Norton 360’s security tools would be worth buying on their own. I’m impressed by how many well-built features each package includes. While I do have some complaints, I still think Norton 360 provides excellent value. That said, Norton’s VPN is still among the best antivirus-bundled VPNs on the market. And while Norton’s VPN offers excellent security features like a no-logs policy, 256-bit AES encryption, and a good network of servers worldwide, it isn’t as fast as competitor VPNs and doesn’t work with all streaming services. Its desktop app is a little clunky, and its mobile protections are split across several separate apps, which is a bit annoying. Norton is the best antivirus around, but it isn’t perfect. During my testing, Norton’s full scan and real-time protection were both able to detect every single malware file I tried to download, with minimal system slowdown and no false positives. Its anti-malware engine uses machine learning, advanced heuristics, and a malware directory to identify malware - from simple viruses and trojans to advanced malware like spyware, ransomware, and cryptojackers. Norton 360 is my favorite antivirus in 2023 - it’s got a powerful anti-malware engine, a wide range of internet security tools, an intuitive online dashboard, and good customer support, all for a better price than most competitors. Angry ip scanner symantec7/12/2023 I suppose don't much understanding of how home networks should work, but I'd like to know more. Many of them pointed to working websites around the country.Īs someone that never ventures out of the 192.168.0.xxx range for setting up the PS4, or my 3d printer Raspberry PI, this seems strange to me. Under hostnames there were thousands of URLs that I don't recognize and have never visited. Out of 65,000 or so hosts scanned, 17000 were ACTIVE. I came across a page of a guy that had written a lot of technical details about how he was able to do it, but it's all stuff that's way out of the ballpark of my understanding.Īnyways, I noticed that his camera was using the IP .x so I decided to run AngryIP scanner on every IP on my home network from 192.241.0.1-192.241.255.255. It also has a few more advanced features not covered in this article, but does have a useful website full of documentation.Īll in all, Angry IP Scanner is a very useful little utility that can potentially save you a lot of time if you have a network at home or in your office.I was playing around with a Funlux camera I bought on Amazon and was googling to see if there was any way I could access the video remotely without using Android. These will launch various built-in Windows tools such as ping, traceroute and so on. There are also a number of tools directly available from the Commands menu, as shown in the screenshot below. The IP address will then appear in the box above.Īngry IP Scanner also allows you to export your results by clicking the Scan menu then Export all (or Export selection). Very powerful if you want to check your network for security holes.Īngry IP Scanner has some other cool features, such as the ability to give you an IP from a given hostname, simply by entering the hostname (it can be a local workgroup hostname or a domain name) and click the little IP button next to it, as per the image below. You need not scan a single IP with this – you can run a port scan on a whole range of IPs. The scan will run and any open ports will show up in the ports column as per the image below. So to scan from ports 10-100, you simply type in 10-100.Ĭlick OK, then click Start. Then select the ports tab, and in the text box at the bottom, enter the port range you wish to scan, as per the image below. If you want to scan ports within a range or just for a specific IP, Angry IP Scanner can do that too! Click on the little tool icon at the end of the first row as per the image below. IP’s that respond will show up with blue icons, and you’ll also see pingtime and hostname details. A list of results will show up as per below. To scan your subnet, simply change the last digit in the first IP sequence to 1, and the last digit of the second IP sequence to 255 and click Start. The IP entered in by default will be that of your own PC. Let’s assume you want to scan your local network to see what devices are connected. Unless you are running a version of Windows earlier than Vista SP2, you need not worry as any connection limitations have been removed.Īfter this initial window, there will a short list of steps that explain some basic terminology and how the program itself works. When you first open Angry IP Scanner, you will likely be asked if you want to find out how to get around the limitations of certain versions of Windows in order to increase scanning speed. Also, do note that you will need to have Java installed (for the Windows version, it should just run on the Mac, and Linux has some other dependencies). Those other items seem to work better on the local subnet though. I like Advanced IP Scanner because it shows user name, NIC manufacturer, shared resources like printers or directories, MAC address. Do keep in mind that this guide is written for Windows, but all that is said here should apply to the other versions. If I need more info, then Nmap is the go to for me. The application is developed in java, so it is cross platforms compatible and works with Windows, Mac and Linux. The first step is to download the appropriate version for your operating system from this page. Symantec security research centers around the world provide unparalleled analysis of and protection from IT security threats that include malware, security risks, vulnerabilities, and spam. |